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The adage that “knowledge is power” is particularly compelling when dealing with issues affecting survival and quality of life, and The Insider’s Guide to Metastatic Breast Cancer is a must-read for every MBC patient.

This Guide was written by a metastatic breast cancer patient with the purpose of helping others cope with this complex and challenging illness.  It is the result of five years of meticulous research, and is updated whenever new therapies are approved or new scientific findings are announced.  For ease of reference, the Guide is available in paperback and eBook formats on Amazon, as well as in a complimentary .pdf. 

You'll read about approved therapies in the US, Canada, Europe, and Australia, as well as scientific studies, cutting edge research, clinical trials, symptom management, and key findings such as:

  • Initial treatment for newly diagnosed patients with hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative disease, should consist of endocrine (hormonal) therapy as per international guidelines - except in case of severe organ dysfunction whereby chemotherapy is recommended.

  • Newly diagnosed Triple Negative (TNBC) MBC patients should consider having their tumors tested for a protein called PD-L1.  If the test is positive, the patient may be a candidate for the newly-approved combination of immunotherapy plus chemotherapy (Atelizumab/Tecentriq + Abraxane) that confers superior treatment response compared with Abraxane alone.

  • Newly diagnosed HER2 positive, HR negative MBC patients should receive initial therapy consisting of Herceptin, Perjeta, and a taxane (unless there is a medical contraindication) because this combination has been shown to increase median overall survival from 40.8 months to 56.5 months.

As one reader summarized, "I have reviewed many books on breast cancer, and for Stage 4 metastatic breast cancer there is no clearer or more informative book on the market."



Anne Loeser is a layperson with decades of firsthand experience with breast cancer.  Her initial encounter occurred in 1993 when, at age 35, she found a lump during a breast self-examination that was misdiagnosed by mammograms and an ultrasound as normal breast tissue.  Four years later, biopsy results revealed Hormone Receptor positive Stage 2 breast cancer (HER2 status was not tested at the time).  Anne underwent a double mastectomy, chemotherapy, and hormonal therapy and remained in remission for several years.

After Anne became hoarse in 2011, a doctor determined that one of her vocal cords was paralyzed.  A subsequent CT scan revealed the presence of multiple lung nodules, malignant pleural effusion, and malignant pericardial effusion.  Subsequent pathology results indicated a recurrence of her original breast cancer.

Anne’s oncologist suggested a clinical trial of an experimental chemotherapy drug (which subsequently failed).  Instead, she consulted a second doctor who recommended endocrine therapy.  Seeking a second medical opinion spared Anne the toxic side effects of chemotherapy, taught her the importance of seeking multiple expert opinions, and emphasized the value of undertaking research when making treatment decisions. 

Despite being a layperson, Anne continued to conduct research regarding MBC and its treatments.  In 2015, she wrote The Insider's Guide to Metastatic Breast Cancer  which she has forwarded in .pdf format upon request to more than 3,200 patients and caregivers worldwide.  She continues to update all 3 versions of the Guide (paperback and eBook on Amazon, and the .pdf) as new research unfolds.  Patients are welcome to order the book or download the .pdf on the ORDER page or by pressing the button below.

A member of the Metastatic Breast Cancer Alliance, Anne has co-authored a peer-reviewed article regarding Atypical Patient Responses that was published in Nature Partner Journal Breast Cancer.

Please note that Anne does not offer medical advice, nor will she accept responsibility for any actions taken (or not taken) by viewers of this site or readers of her book or .pdf.

It is Anne’s hope that the information provided in The Insider's Guide to Metastatic Breast Cancer will enable you or a loved one to attain the best possible outcome and quality of life.